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Pentobarbital is used short-term to treat insomnia. Pentobarbital is also use as an emergency treatment for seizures, and to cause you to fall asleep for surgery.
In high doses, pentobarbital causes death by respiratory arrest. In the United States, the drug has been use for executions of convicted criminals.

1. Medical use:

Typical applications for pentobarbital are sedative, hypnotic for short term, preanesthetic and control of convulsions in emergencies.

It is also used as a veterinary anesthetic agent.

Pentobarbital also has an application in reducing intracranial pressure in Reye’s syndrome, traumatic brain injury and induction of coma in cerebral ischemia patients. Pentobarbital-induced coma has been advocate in patients with acute liver failure refractory to mannitol.

2. Euthanasia or physician-assisted dying

Pentobarbital can induce death when used in high doses. It is use for euthanasia for humans as well as animals. It’s also use by itself, or in combination with complementary agents such as phenytoin, in commercial animal euthanasia injectable solutions.

In the Netherlands, the standard protocol for physician-assisted suicide is intravenously induce thiopental anesthesia, follow by bromide of alcuronium- or pancuronium-induced respiratory arrest. A concentrated oral solution of 100 mL containing 9 grams of pentobarbital sodium along with sugar syrup in a 20% ethanol solution is a standard solution use for self-administration by patient.

The oral dosage of pentobarbital indicated for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January, 2016) is typically 10 g in liquid form.

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